Structural analysis of histamine receptors and its application in drug design PhD theses
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The role of histamine receptors in restraint stress-induced immunosuppression in the rat brain
Restraint-induced stress (RS) increases histamine concentration in the brain. There is no previous report regarding the role of histamine receptors in immunomodulatory effect of RS. In the present study the role of brain histamine receptors on reduction of humoral and cellular immune function induced by RS was evaluated. For this purpose male Wistar rats (200-250 g) were immunized with sheep re...
متن کاملاثر گیرندههای دوپامینی D1 هیپوکامپ پشتی بررفتار اضطرابی القا شده با هیستامین در موش کوچک آزمایشگاهی
Background and Objective: Dopamine receptors and histamine influence anxiety-like behaviors. Furthermore, interaction between histamine and dopaminergic D1 receptors has been demonstrated in the modulation of some behavior. In the present study, we investigated the interaction between histamine and dopaminergic D1 receptors in the dorsal hippocampus in the anxiety behavior. Materials and Method...
متن کاملInteractions between Histamine H1 and H3 and Dopamine D1 Receptors on feeding behavior in chicken
BACKGROUND: Brain monoamines (such as histamine and dopamine) play an important role in emotions, cognition, reward and feeding behavior. The interactions between histamine and dopamine were studied in many physiological functions but this correlation is unclear in feeding behavior of chickens. The aim of this study was to investigate the interaction of central histaminergic and dopaminergic sy...
متن کاملThe effect of bromocriptine on basal and histamine-stimulated gastric acid secretion in anesthetized rats
Introduction: The protective and antisecretory effects of dopamine agonists on the stomach have been already reported, but the effect of bromocriptine (D2 dopamine agonist) on histamine stimulated gastric acid secretion (GAS) needs to be investigated. Methods: For gastric sampling, animals were anesthetized and a polyethylen tube was introduced into the stomach through esophagus. A cannula ...
متن کاملContribution of potassium channels, beta2-adrenergic and histamine H1 receptors in the relaxant effect of baicalein on rat tracheal smooth muscle
Objective(s): Baicalein, a compound extracted from a variety of herbs, showed various pharmacological effects. This study evaluated the relaxant effects of baicalein and its underlying molecular mechanisms of action on rat’s isolated tracheal smooth muscle.Materials and Methods: Tracheal smooth muscle were contracted by 10 μM methacholin...
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